Research | Akkaya Lab

Cerebral Malaria Is Regulated by Host-Mediated Changes in Plasmodium Gene Expression

Clare K. Cimperman, Mirna Pena, Sohret M. Gokcek, Brandon P. Theall, Meha V. Patel, Anisha Sharma, ChenFeng Qi, Daniel Sturdevant, Louis H. Miller, Patrick L. Collins, Susan K. Pierce, Munir Akkaya

mBio · 28 Feb 2023

Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment

Bayley R. McRitchie, Billur Akkaya

Frontiers in Immunology · 30 Sep 2022

Regulatory T cells: Master thieves of the immune system

Billur Akkaya, Ethan M. Shevach

Cellular Immunology · 01 Sep 2020

A single-nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity

Munir Akkaya, Abhisheka Bansal, Patrick W. Sheehan, Mirna Pena, Alvaro Molina-Cruz, Lindsey M. Orchard, Clare K. Cimperman, Chen-Feng Qi, Philipp Ross, Takele Yazew, Daniel Sturdevant, Sarah L. Anzick, Girija Thiruvengadam, Thomas Dan Otto, Oliver Billker, Manuel Llinás, Louis H. Miller, Susan K. Pierce

Science Advances · 07 Feb 2020

B cell memory: building two walls of protection against pathogens

Munir Akkaya, Kihyuck Kwak, Susan K. Pierce

Nature Reviews Immunology · 13 Dec 2019

T-Cells Tumor Immunotherapy

B cell signaling in context

Kihyuck Kwak, Munir Akkaya, Susan K. Pierce

Nature Immunology · 08 Jul 2019

From zero to sixty and back to zero again: the metabolic life of B cells

Munir Akkaya, Susan K Pierce

Current Opinion in Immunology · 01 Apr 2019

Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells

Billur Akkaya, Yoshihiro Oya, Munir Akkaya, Jafar Al Souz, Amanda H. Holstein, Olena Kamenyeva, Juraj Kabat, Ryutaro Matsumura, David W. Dorward, Deborah D. Glass, Ethan M. Shevach

Nature Immunology · 14 Jan 2019

Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4⁺ T Cell Activation

Billur Akkaya, Alexander S. Roesler, Pietro Miozzo, Brandon P. Theall, Jafar Al Souz, Margery G. Smelkinson, Juraj Kabat, Javier Traba, Michael N. Sack, Joseph A. Brzostowski, Mirna Pena, David W. Dorward, Susan K. Pierce, Munir Akkaya

The Journal of Immunology · 29 Oct 2018

Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

Munir Akkaya, Javier Traba, Alexander S. Roesler, Pietro Miozzo, Billur Akkaya, Brandon P. Theall, Haewon Sohn, Mirna Pena, Margery Smelkinson, Juraj Kabat, Eric Dahlstrom, David W. Dorward, Jeff Skinner, Michael N. Sack, Susan K. Pierce

Nature Immunology · 09 Jul 2018

Toll-like receptor 9 antagonizes antibody affinity maturation

Munir Akkaya, Billur Akkaya, Ann S. Kim, Pietro Miozzo, Haewon Sohn, Mirna Pena, Alexander S. Roesler, Brandon P. Theall, Travis Henke, Juraj Kabat, Jinghua Lu, David W. Dorward, Eric Dahlstrom, Jeff Skinner, Louis H. Miller, Susan K. Pierce

Nature Immunology · 23 Feb 2018

T cell-dependent antigen adjuvanted with DOTAP-CpG-B but not DOTAP-CpG-A induces robust germinal center responses and high affinity antibodies in mice

Munir Akkaya, Billur Akkaya, Patrick W. Sheehan, Pietro Miozzo, Mirna Pena, Chen-Feng Qi, Javier Manzella-Lapeira, Silvia Bolland, Susan K. Pierce

European Journal of Immunology · 21 Aug 2017

B Cells Produce Type 1 IFNs in Response to the TLR9 Agonist CpG-A Conjugated to Cationic Lipids

Munir Akkaya, Billur Akkaya, Pietro Miozzo, Mukul Rawat, Mirna Pena, Patrick W. Sheehan, Ann S. Kim, Olena Kamenyeva, Juraj Kabat, Silvia Bolland, Akanksha Chaturvedi, Susan K. Pierce

The Journal of Immunology · 26 Jun 2017

Ex-vivo iTreg differentiation revisited: Convenient alternatives to existing strategies

Billur Akkaya, Amanda H. Holstein, Christopher Isaac, Mitra P. Maz, Deborah D. Glass, Ethan M. Shevach, Munir Akkaya

Journal of Immunological Methods · 01 Feb 2017

An Optimized Protocol to Analyze Glycolysis and Mitochondrial Respiration in Lymphocytes

Javier Traba, Pietro Miozzo, Billur Akkaya, Susan K. Pierce, Munir Akkaya

Journal of Visualized Experiments · 21 Nov 2016

The Regulation of Inherently Autoreactive VH4-34–Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa

Geoffrey T. Hart, Munir Akkaya, Asiya S. Chida, Chungwen Wei, Scott A. Jenks, Christopher Tipton, Chenfeng He, Ben S. Wendel, Jeff Skinner, Gunjan Arora, Kassoum Kayentao, Aissata Ongoiba, Ogobara Doumbo, Boubacar Traore, David L. Narum, Ning Jiang, Peter D. Crompton, Ignacio Sanz, Susan K. Pierce

The Journal of Immunology · 19 Oct 2016

A Simple, Versatile Antibody-Based Barcoding Method for Flow Cytometry

Billur Akkaya, Pietro Miozzo, Amanda H. Holstein, Ethan M. Shevach, Susan K. Pierce, Munir Akkaya

The Journal of Immunology · 20 Jul 2016

Rabbit CD200R binds host CD200 but not CD200-like proteins from poxviruses

Munir Akkaya, Lai-Shan Kwong, Erdem Akkaya, Deborah Hatherley, A. Neil Barclay

Virology · 01 Jan 2016

Herpesvirus orthologues of CD200 bind host CD200R but not related activating receptors

Lai Shan Kwong, Munir Akkaya, A. Neil Barclay, Deborah Hatherley

Journal of General Virology · 01 Jan 2016

Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

Emile B. Gordon, Geoffrey T. Hart, Tuan M. Tran, Michael Waisberg, Munir Akkaya, Ann S. Kim, Sara E. Hamilton, Mirna Pena, Takele Yazew, Chen-Feng Qi, Chen-Fang Lee, Ying-Chun Lo, Louis H. Miller, Jonathan D. Powell, Susan K. Pierce

Proceedings of the National Academy of Sciences · 05 Oct 2015

Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria

Emile B. Gordon, Geoffrey T. Hart, Tuan M. Tran, Michael Waisberg, Munir Akkaya, Jeff Skinner, Severin Zinöcker, Mirna Pena, Takele Yazew, Chen-Feng Qi, Louis H. Miller, Susan K. Pierce

mBio · 01 Jul 2015