Research output
Publications
Research from the Akkaya Lab spanning T-cell regulation, B-cell biology, immune metabolism, neuroimmunology and computational immunology.
2026
Mechanobiology of regulatory T cells: how cellular mechanics shape immune suppressionnpj Biological Physics and Mechanics · Arteaga-Muñiz VI, Singh V, Akkaya B, Kural C
T Cell
2025
In the activation of HPV-specific human B cells HPV-VLP vaccines mimic membrane-associated antigensProceedings of the National Academy of Sciences · Torgbor C, Sohn H, Dizon BLP, Mutic EC, George R, Kwak K, Akkaya M, Ulker EB, Traver M, Brzostowski J, Galloway DA, Thompson CD, Çuburu N, Schiller JT, Pierce SK
B Cell
2025
Disrupting explicit encoding paradigms: property-interactive transformers decode T-cell receptor specificity beyond dataset biasesBriefings in Bioinformatics · Yang L, Liu H, Calanche A, Gokcek SM, Singh V, Sansoterra N, Akkaya M, Akkaya B, Yilmaz A
Shared / Computational
2024
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatasesImmunity · Lippert AH et al., including Akkaya B
T Cell
2024
Illuminating T cell-dendritic cell interactions in vivo by FlAsHing antigens.eLife · Akkaya M, Al Souz J, Williams D, Kamdar R, Kamenyeva O, Kabat J, Shevach E, Akkaya B
T Cell
2024
Editorial: Targeting regulatory cells in cancer: old and new approaches in immunotherapyFrontiers in Immunology · Cari L, Sorrentino R, Akkaya B, Nocentini G
T Cell
2023
Illuminating T cell-dendritic cell interactions in vivo by FlAsHing antigens.Research square · Akkaya M, Al Souz J, Williams D, Kamdar R, Kamenyeva O, Kabat J, Shevach EM, Akkaya B
T Cell
2020
B cell memory: building two walls of protection against pathogens.Nature reviews. Immunology · Akkaya M, Kwak K, Pierce SK
B Cell
2020
A single-nucleotide polymorphism in a ApiAP2 transcription factor alters the development of host immunity.Science advances · Akkaya M, Bansal A, Sheehan PW, Pena M, Molina-Cruz A, Orchard LM, Cimperman CK, Qi CF, Ross P, Yazew T, Sturdevant D, Anzick SL, Thiruvengadam G, Otto TD, Billker O, Llinás M, Miller LH, Pierce SK
B Cell
2019
B cell signaling in context.Nature immunology · Kwak K, Akkaya M, Pierce SK
B Cell
2019
Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells.Nature immunology · Akkaya B, Oya Y, Akkaya M, Al Souz J, Holstein AH, Kamenyeva O, Kabat J, Matsumura R, Dorward DW, Glass DD, Shevach EM
Shared / Computational
2018
Toll-like receptor 9 antagonizes antibody affinity maturation.Nature immunology · Akkaya M, Akkaya B, Kim AS, Miozzo P, Sohn H, Pena M, Roesler AS, Theall BP, Henke T, Kabat J, Lu J, Dorward DW, Dahlstrom E, Skinner J, Miller LH, Pierce SK
Shared / Computational
2018
Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4 T Cell Activation.Journal of immunology (Baltimore, Md. : 1950) · Akkaya B, Roesler AS, Miozzo P, Theall BP, Al Souz J, Smelkinson MG, Kabat J, Traba J, Sack MN, Brzostowski JA, Pena M, Dorward DW, Pierce SK, Akkaya M
Shared / Computational
2018
Second signals rescue B cells from activation-induced mitochondrial dysfunction and death.Nature immunology · Akkaya M, Traba J, Roesler AS, Miozzo P, Akkaya B, Theall BP, Sohn H, Pena M, Smelkinson M, Kabat J, Dahlstrom E, Dorward DW, Skinner J, Sack MN, Pierce SK
Shared / Computational
2017
T cell-dependent antigen adjuvanted with DOTAP-CpG-B but not DOTAP-CpG-A induces robust germinal center responses and high affinity antibodies in mice.European journal of immunology · Akkaya M, Akkaya B, Sheehan PW, Miozzo P, Pena M, Qi CF, Manzella-Lapeira J, Bolland S, Pierce SK
B Cell
2017
B Cells Produce Type 1 IFNs in Response to the TLR9 Agonist CpG-A Conjugated to Cationic Lipids.Journal of immunology (Baltimore, Md. : 1950) · Akkaya M, Akkaya B, Miozzo P, Rawat M, Pena M, Sheehan PW, Kim AS, Kamenyeva O, Kabat J, Bolland S, Chaturvedi A, Pierce SK
Shared / Computational
2016
The Regulation of Inherently Autoreactive VH4-34-Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa.Journal of immunology (Baltimore, Md. : 1950) · Hart GT, Akkaya M, Chida AS, Wei C, Jenks SA, Tipton C, He C, Wendel BS, Skinner J, Arora G, Kayentao K, Ongoiba A, Doumbo O, Traore B, Narum DL, Jiang N, Crompton PD, Sanz I, Pierce SK
B Cell
2016
A Simple, Versatile Antibody-Based Barcoding Method for Flow Cytometry.Journal of immunology (Baltimore, Md. : 1950) · Akkaya B, Miozzo P, Holstein AH, Shevach EM, Pierce SK, Akkaya M
Shared / Computational