The people behind the science.
One lab, two complementary programs, and a team that works across the boundary between them.
Principal Investigators

Billur Akkaya, MD, DPhil
Billur Akkaya studies regulatory T-cell biology, antigen-specific immune tolerance and neuroimmunology, with an emphasis on how Tregs interact with antigen-presenting cells and shape immune responses.
Full bio
Billur Akkaya received her MD from Hacettepe University in 2008 and her DPhil from the University of Oxford in 2013. She completed postdoctoral training in the Laboratory of Immune System Biology at the National Institute of Allergy and Infectious Diseases, NIH, and established her laboratory at The Ohio State University in 2021. Her research focuses on regulatory T-cell biology, antigen-specific immune suppression, Treg–antigen-presenting cell interactions and neuroimmunology, with applications in autoimmunity and cancer. She received the 2022 NIAID New Innovator Award (DP2) for work on the specificity and molecular mechanisms of regulatory T cells. Outside the lab, Billur and Münir are active runners and members of Run Columbus. Both are marathoners and regularly train and race distances from the 5K through the marathon.

Munir Akkaya, MD, DPhil
Munir Akkaya studies B-cell activation, immunometabolism and cell-fate decisions, including how BCR, innate and metabolic signals are integrated over time.
Full bio
Munir Akkaya received his MD from Hacettepe University in 2007 and his DPhil from the University of Oxford in 2012. He completed postdoctoral training at NIAID, NIH, where his work focused on B-cell biology and immunometabolism. His laboratory studies how B-cell receptor, Toll-like receptor and metabolic signals interact to control activation, survival and differentiation, and how these mechanisms influence autoimmunity, host–pathogen interactions and vaccine responses. His current NIGMS Maximizing Investigators’ Research Award (R35 MIRA) supports work to define the molecular logic of immune-cell fate decisions. Outside the lab, Billur and Münir are active runners and members of Run Columbus. Both are marathoners and regularly train and race distances from the 5K through the marathon.
Current team

Vishal Singh, PhD
Vishal studies regulatory T-cell biology, antigen-presenting-cell interactions and AI-guided TCR antigen discovery in autoimmune and inflammatory disease.
Full bio
Vishal Singh is a Postdoctoral Fellow in the Akkaya Lab. His current research focuses on regulatory T cells and their role in autoimmune and inflammatory diseases, including LAG-3-mediated interactions between regulatory T cells and antigen-presenting cells and antigen-specific immune regulation in experimental cerebral malaria. He also contributes to AI-guided antigen discovery, integrating computational predictions with experimental validation to investigate T-cell receptor specificity in cancer and type 1 diabetes. Vishal earned his Ph.D. in Biochemistry from Panjab University in 2021, with doctoral work in nanotherapeutics and metabolic disease, and later pursued research in nanomedicine and point-of-care biosensing. His long-term goal is to combine immunology and nanomaterials to develop targeted therapies for disease-associated immune dysfunction.

Alec Calanche
Alec studies the mechanisms underlying regulatory T-cell suppressive function and their potential as immunotherapies.
Full bio
A Columbus, Ohio native, Alec earned his B.S. from The Ohio State University in 2024 with majors in Biochemistry, Molecular Genetics, and Biology. As an undergraduate, he completed an internship with the Department of Biomedical Informatics analyzing bone marrow-derived multi-omics data to investigate hematopoiesis. He joined the Akkaya Lab as a Research Technician, where his work focuses on the mechanisms underlying regulatory T-cell suppressive function and their potential applications as immunotherapies. He plans to pursue a Ph.D. and continue investigating regulatory T cells in multiple sclerosis and other immune-mediated diseases. Outside the lab, Alec enjoys spending time with friends and restoring vintage furniture.

Tony Nguyen
Tony studies how PI3K signaling regulates regulatory T-cell function and immune tolerance in steady-state and neuroinflammatory settings.
Full bio
Tony is from Northern Virginia and earned his B.S. in Neuroscience from George Mason University in 2022, where he received the Neuroscience Faculty Choice Award and Outstanding Neuroscience Senior Award. His undergraduate research included zebrafish neurodevelopment and traumatic brain injury. He then spent more than two years at the NIH/NIA studying CD8+ T cells in mouse models of Alzheimer’s disease. Tony is now a Ph.D. student in the Neuroscience Graduate Program at The Ohio State University. In the Akkaya Lab, he studies how PI3K signaling regulates regulatory T-cell function and immune tolerance at steady state and under neuroinflammatory conditions. Outside research, he has a background in studio arts, serves as a senior editor for Knowing Neurons, and enjoys cooking and morning runs.

Ece Erci, MD
Ece studies B-cell metabolism, using chronic lymphocytic leukemia models to probe metabolic pathways and cellular responses.
Full bio
Ece is a pediatrician originally trained in Turkey and currently works as a Research Technician. Her research focuses on B-cell metabolism, including the use of chronic lymphocytic leukemia (CLL) cell lines to investigate metabolic pathways and cellular responses under different experimental conditions. Outside the bench, she enjoys yoga, hiking, traveling, and an ongoing search for the best matcha in Columbus – a research project with no expected completion date.

Remy Pastierik
Remy studies the B-cell metabolic clock and how metabolic dysregulation contributes to abnormal B-cell survival and disease progression.
Full bio
Remy is a graduate student in the Molecular, Cellular, and Developmental Biology program at The Ohio State University. Originally from Pittsburgh, Pennsylvania, Remy earned a B.S. in Biological Science and an M.A.T. in Secondary Science Education from Duquesne University. Remy’s research focuses on the B-cell metabolic clock and how cellular metabolism influences B-cell fate and function, with applications to chronic lymphocytic leukemia (CLL) and abnormal B-cell survival.

Sohret Meryem Gokcek
Meryem studies obesity-associated changes in B-cell function and how metabolic cues shape immune responses and tolerance.
Full bio
Meryem is originally from Izmir, Türkiye, and is a Ph.D. student in the Biomedical Sciences Graduate Program at The Ohio State University, specializing in Immunology. She earned her B.S. in Molecular Biology and Genetics from Gebze Technical University, graduating among the university’s top students. In the Akkaya Lab, she studies obesity-associated changes in B-cell function using human and mouse systems, with a focus on how B-cell-intrinsic signaling links metabolic cues to immune responses and tolerance. Outside the lab, she enjoys art performances, cooking, and spending time with friends.

Jen Spires
Jen studies the roles of Lyn and PI3Kδ in B-cell receptor signaling using mouse models.
Full bio
Jen is a second-year master’s student in the Immunology and Microbial Pathogenesis program at The Ohio State University, where she also earned her bachelor’s degree in Biology. In Munir Akkaya’s lab, she uses Lyn knockout and PI3Kδ mouse models to study their roles in B-cell receptor signaling. Outside the lab, she enjoys trying new restaurants and cafés with friends and traveling.

Declan Toohey
Declan is a second-year Biology student interested in medicine and surgery.
Full bio
Declan is a second-year student majoring in Biology. Outside academics, he enjoys playing sports, reading, and watching new movies. He hopes to attend medical school and eventually work in the operating room.

Kate Hill
Kate is a third-year Biology major on the pre-med track with a minor in Psychology.
Full bio
Kate is a third-year undergraduate student majoring in Biology on the pre-med track with a minor in Psychology. Outside academics, she enjoys volunteering, swimming, and spending time with friends. She plans to pursue a career in Pediatrics or Family Medicine.

Harkirat Kaur
Harkirat is a Pharmaceutical Sciences student on the pre-med track and works on the T-cell side of the lab.
Full bio
Harkirat is from Dublin, Ohio, and is a sophomore majoring in Pharmaceutical Sciences on the pre-med track. She is a research assistant on the T-cell side of the Akkaya Lab. Outside the lab, she enjoys cooking, reading, volunteering, and getting involved in campus activities.

Niko Dounoulis
Niko is a third-year undergraduate student on the pre-med track studying applied mathematics in chemistry with a minor in Human Anatomy.
Full bio
Niko is a third-year undergraduate student at The Ohio State University from the Atlantic City, New Jersey area. He is pursuing a B.S. in Applied Mathematics in Chemistry with a minor in Human Anatomy and is on the pre-medical track. Outside academics, he enjoys spending time with friends, reading, traveling, and trying new restaurants.

Claire Zeigler
Claire is a third-year Biomedical Science student on the pre-med track.
Full bio
Claire is a third-year undergraduate student majoring in Biomedical Science on the pre-med track. Outside school, she enjoys running, playing pickleball, exploring new coffee shops in Columbus, and supporting the Buckeyes at football games. She plans to pursue a career in orthopedic surgery or emergency medicine.

Samantha Massien
Samantha is a fourth-year honors Health Sciences student on the pre-med track.
Full bio
Samantha is a fourth-year honors undergraduate student studying Health Sciences on the pre-med track. Outside research, she is a manager at Ohio State’s Recreational and Physical Activity Center, Vice President of the Ohio State CHAARG chapter, a working phlebotomist, and a founding member of the Ohio State branch of Alpha Lambda Delta Honor Society. She hopes to pursue a career in cardiology or interventional radiology after medical school.

Sushant Gundrathi
Sushant is a second-year Biology major who plans to pursue medicine.
Full bio
Sushant is a second-year Biology major. Outside academics, he enjoys hiking and playing sports with friends. He plans to attend medical school and become a physician.

Daniel Petrowsky
Daniel is a fourth-year Molecular Genetics student interested in immunology and medicine.
Full bio
Daniel is a fourth-year undergraduate student studying Molecular Genetics and is from Columbus, Ohio. He is interested in immunology research and plans to attend medical school in the future.

Ryu Miller
Ryu is an Ohio State Biology graduate who continues research on the B-cell side of the lab as a volunteer researcher.
Full bio
Ryu earned a B.S. in Biology from The Ohio State University and continues to work on the B-cell side of the Akkaya Lab as a volunteer researcher. Born and raised in Columbus, Ohio, Ryu plans to attend medical school. Outside the lab, he enjoys playing the violin, reading, and traveling.

Will Simcic
Will is a senior Microbiology major interested in cellular processes including gene expression and protein synthesis.
Full bio
Will is a senior majoring in Microbiology at The Ohio State University and is from Worthington, Ohio. He enjoys learning about and researching cellular processes such as gene expression and protein synthesis.
Meet the A-Team.
A playful corner for the people who make the work happen—without replacing the formal Akkaya Lab identity.